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For oral steroid therapy, patients received 60 milligrams of prednisone for 14 days, followed by a tapering-off period of 5 days; the next dose at 7 days was followed by 1 day of placebo for the duration of oral steroid therapy and then tapering-off every 4 weeks. The patients in this study were generally younger (mean 27.8 years old), and fewer had prior steroid-related bone fractures other than non-contact fractures. Two studies (N=912) conducted between 1994 and 1998 compared the benefits of oral prednisolone (prednisone-spironolactone acetate [R] and rosiglitazone) versus placebo. A total of 17 patients (8 males and 7 females) treated in these studies were followed for an average of 6.4 years. There were 7 patients with at least one of several different fracture sites, although none of these fractures resulted in long-term adverse outcomes. Two patients who received no oral prednisone therapy had bone fractures. The primary outcome was the difference in the rate of non-contact fractures of 1, 2, or 5% from the placebo group to the prednisone group that occurred on at least one of the baseline examinations. The primary outcome was a secondary outcome that assessed the severity of the fracture on at least one preoperative examination. No significant differences were found in this subgroup among the three studies. A third study of 50 subjects (n=15 males and 15 females) was conducted between 1988 and 1990. Ten patients received a single dose of prednisone or a placebo twice daily for 8 weeks as a single bolus at a dose of 150 mg (8 mg on day 1, 250 mg on day 2, and 300 mg on day 3), followed by 2 weeks of tapering-off. Patients had normal bone mineral density and normal results on bone mineral testing, and none of the treated patients had long-term bone fractures other than non-contact fractures (including a single fracture for which surgical exploration and reattachment was recommended). Most individuals in the prednisolone group experienced bone density losses at the time of surgery that were less than 1 sd higher than that observed for the placebo group, which were similar to that seen in patients receiving tapering-off injections. The duration of treatment in the prednisolone group was 10 hours, whereas the duration in the placebo group was 6 hours. The treatment regimen produced a small increase in the rate of fractures; however, the study results did not indicate an increased risk of fractures after therapy was ended. There was one report that included data from both series of patients; in Similar articles: