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Patients with polymyalgia rheumatica who develop clear evidence of giant cell arteritis should be treated with a corticosteroid in the high dosage appropriate for giant cell arteritisfor 2 to 4 weeks. The patient should be monitored daily for side effects such as fever, malaise, fatigue, headache, dizziness, myalgia, pain, swelling, bruising or rash. Other side effects such as dry mouth, rash, red, swollen lymph nodes and fever are not uncommon.Other DrugsTriptansThe use of triptans (triptansulfonamide or triptans) is uncommon. Although triptansulfonamide, the brand name for a short-acting triptan known as tasoteron, and tasoterone (tasoterone citrate) may be helpful in short-term treatment, the drug's long-term benefits are not known.PhenytoinPhenytoin is a potent vasodilator in patients with polymyalgia rheumatica. It has been used in clinical trials for the treatment of acute coronary syndrome and severe angina in patients with rheumatic symptoms. The drug's action on the vascular system during vasodilatory actions is unknown.AnticoagulantsSeveral anticoagulants have been tested in patients with polymyalgia rheumatica. These drugs are generally considered safe and well tolerated, and may be effective.Fluoxetine has been tested, and in some cases, used. Fluoxetine has been shown in the past to be useful for the management of other disorders such as major depression. However, there is no evidence from long-term studies that it is effective in treating polymyalgia rheumatica. It has been shown to suppress the growth of certain microclones of human neutrophils and to potentiate their activity as micro-inflammatories by inducing their activation.Doxycycline is an effective antidepressant agent in patients with rheumatic symptomatology. It was studied in a group of patients on a serotonin-reuptake inhibitor (SSRI) drug trial, and a study of 15 patients with polymyalgia rheumatica were not sufficient to show that it will be useful in that group. However, in a study of 16 patients with polymyalgia rheumatica, 16 received 2 weeks of doxycycline (15 mg daily). The primary endpoint was the change in the presence of symptoms. Improvement in mood was measured by using the Modified Rankin Scale of Hyperactivity and Hypertonic Reaction. The investigators found a decreaseRelated Article: